- Postdoctoral Affiliate
- MRC Postdoctoral Fellow, MRC Toxicology Unit
Dr Grace Jean Campbell completed her PhD at the University of Sydney, Australia, in 2020 where she examined the effects of maternal nutrition on offspring metabolic programming in mice. Following from her PhD, Jean continues to use molecular biology to interrogate how the maternal environment alters foetal development in mice, now with a focus on toxicology. Jean is currently an MRC Postdoctoral Fellow at the MRC Toxicology Unit, University of Cambridge.
Dr Grace Jean Campbell’s research involves exploring the developmental defects due to prenatal exposure to a class of drugs that act by inhibiting histone deacetylases. Histone deacetylases are enzymes that remove acetyl groups from histones, the proteins that DNA is wrapped around within a cell. By inhibiting these enzymes, these drugs directly affect how open or closed DNA chromosomes are, potentially drastically affecting gene expression. Some of these drugs have clinical applications, including as treatment for epilepsy and various psychiatric disorders, or as a dietary supplement to alleviate digestive ailments. Due
to their impact on gene expression, when taken during pregnancy they can severely alter the development of a growing foetus. Jean’s research involves the use of both stem cell and mouse models to investigate the molecular mechanisms behind these deleterious effects, with a particular focus on sex-specific differences in the developing offspring.